Endocrine Abstracts

Introduction: Pancreatic neuroendocrine tumours (pNETs) can either occur in patients with a familial syndrome, like multiple endocrine neoplasia type 1 (MEN-1), or being sporadic. In the last decade, endoscopic ultrasound (EUS) has become one of the first-line investigations for the characterisation of pNETs. The ultrasonographic features of a pNET might differ depending on the familial vs sporadic pathogenesis of the tumour. Therefore, the EUS findings might help and direct t...

Objective: A cytosine-adenine (CA)n microsatellite repeat polymorphism in the promoter region of the insulin-like growth factor-1 (IGF-1) gene has reported to be associated with IGF-1 serum levels, birth weight, body height, bone mineral density and risk for type 2 diabetes and myocardial infarction. Carriers and non-carriers of the most frequent allele (length 192 base pairs (bp)) showed significantly different total IGF-1 serum levels. This polymorphism may direct...